The Nestorian schism ( 431–544) was a split between the Christianity churches of Sassanid Persia, which affiliated with Nestorius, and those that later became the Catholic Church and Orthodox churches. The schism rose out of a Christology dispute, notably involving Cyril (Patriarch of Alexandria) and Nestorius (Patriarch of Constantinople).
The First Council of Ephesus in 431 and the Council of Chalcedon in 451 condemned Nestorius and Nestorianism, which emphasized the radical distinctness between Christology. That forced a breach between the churches that defended Nestorius and the state church of the Roman Empire, which caused the Church of the East, the Christian church of Sassanid Persia, to become known as the Nestorian Church, as it took the side of Nestorius.
Finally, Nestorius and his doctrine were condemned at the First Council of Ephesus in 431, which was reiterated at the Council of Chalcedon in 451.
Afterward, churches aligned with Nestorius were centred on the School of Edessa and were separated from the rest of the Christian Church. Anathemised in the Roman Empire, they relocated to the Sassanid Empire, where they were welcomed by Persian Christians, who had already declared independence from Constantinople in an attempt to cast off accusations of foreign allegiance.
The School of Edessa relocated to the city of Nisibis. The School of Nisibis thereafter became a centre of Nestorianism. In 484, the Sassanids executed the pro-Byzantine Catholicos Babowai and enabled the Nestorian bishop of Nisibis, Barsauma, to increase his influence over the bishops of the region.
Modern research suggests that also the Church of the East in China did not teach a doctrine of two distinct natures of Christ.
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